This study was conducted to identify and assess association between the socio-demographic characteristics, the potential barriers, the level of knowledge, attitude and practice regarding exclusive breastfeeding (EBF) during the first 6 months after birth among mothers of babies aged 6-18 months in CHILILAB, Chi Linh town, Hai Duong province, Vietnam. There were 223 participants selected to join this study by simple random sampling from the CHILILAB office database.