This study was conducted to identify and assess association between the socio-demographic characteristics, the potential barriers, the level of knowledge, attitude and practice regarding exclusive breastfeeding (EBF) during the first 6 months after birth among mothers of babies aged 6-18 months in CHILILAB, Chi Linh town, Hai Duong province, Vietnam. There were 223 participants selected to join this study by simple random sampling from the CHILILAB office database. In this cross-sectional study, all participants were interviewed face to face, using a standardized questionnaire with 55 questions. 48% of participants reported that they breastfed exclusively during the first 6 months after birth, but only 29% did so under a strict definition of exclusive breastfeeding. The high education participants intended to have more knowledge about EBF than the low education participants and the participants who work for government or services or trading also had more knowledge about EBF than others jobs (p=0.002 and 0.038, respectively) while the 26 – 30 age group intended to have more positive attitude about EBF than other age groups (p=0.012). The lower education participants and the famer both intended to higher self – reported EBF more than the higher education participants and others jobs (p